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2015 Committee Officer and Member Roster
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2015 Officers

Chair
Paul J. Sideris
Queensborough Community College
Department of Chemistry
222-05 56th Avenue
Bayside, NY, 11364
Phone: 718-281-5615
Email

Chair-Elect
Kevin Kolack
Queensborough Community College
Department of Chemistry
222-05 56th Ave
Bayside, NY, 11364
Phone: 718-281-5037
Email

Chair-Past
Marlon Moreno
Queensborough Community College
Department of Chemistry
222-05 56th Ave
Bayside, NY, 11364
Email

Secretary
Terry Brack
Hofstra University
Department of Chemistry
Hempstead, NY, 11549-0151
Phone: 516-463-5539
Email

Treasurer
Philip Mark
Nassau Community College
Department of Chemistry
One Education Drive
Garden City, NY, 11530
Email

Directors
Ralph Stephani
St.John's University
Department of Chemistry
8000 Utopia Parkway
Jamaica, NY, 11439-0001
Phone: 718-990-5215
Email

Daniel Resch
Nassau Community College
Department of Chemistry
One Education Drive
Garden City, NY, 11530
Email

Sujun Wei
Queensborough Community College
Department of Chemistry
222-05 56th Ave
Bayside, NY, 11364
Phone: 718-631-6939
Email

Terrence M. Black
Nassau Community College
Department of Chemistry
One Education Drive
Garden City, NY, 11530
Phone: 516-463-6277
Email




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Department of Chemistry
St. John's University
8000 Utopia Parkway
Jamaica, NY 11439
Phone 516-883-7510
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LONG ISLAND SUBSECTION



Our monthly seminars cover a broad range of topics and are open to all.
Students are encouraged to attend.

Queensborough Community College
Science Building, Room S-112
Directions
Social: 5:30 pm Seminar: 6:00 PM
Cost: Seminar is free and open to all
Dinner: Following at a nearby restaurant ($25)

Photos from Spring 2014 Events



2015 Meetings

February 5, 2015

Tony Taldone, Ph.D., Senior Research Scientist, Memorial Sloan Kettering Cancer Center

Discovery and Development of Purine-scaffold Hsp90 inhibitors for the Treatment of Cancer

Heat shock protein 90 (Hsp90) is a molecular chaperone exploited by cancer cells to aid in their survival. The recognition of Hsp90 as a critical facilitator for oncogene addiction and survival of cancer cells has opened a promising new niche for cancer treatment. The serendipitous discovery that the broad spectrum anticancer activity of the natural products geldanamycin (GM) and radicicol (RD) was a result of inhibition of Hsp90 resulted in the development of improved derivatives of these natural products. One of these was 17-AAG, a closely related analog of GM, and was in fact the first Hsp90 inhibitor to enter the clinic. However, GM and its analogs suffer from poor 'drug-like' properties and this served as a strong impetus for the development of novel synthetic Hsp90 inhibitors. One class to exhibit enhanced potency and improved pharmacokinetic properties is the purine-scaffold. A number of small-molecule Hsp90 inhibitors based on the purine-scaffold are currently being evaluated in clinical trials for cancer. Here, I will discuss their initial discovery and development into potential anticancer agents.


March 5, 2015

Ling Huang, Ph.D., Department of Chemistry, Hofstra University

'Spice Tales': Rapid Detection and Quantification of Synthetic Cannabinoids

Since 2008, Designer drugs such as synthetic cannabinoids mixed with herbal products, also known as ’Spice’ have been sold as herbal incenses in smoke shops and online. Many synthetic cannabinoids have been outlawed as Schedule I controlled substance. New and 'legal’ compounds are still being sold around the world, which creates challenges to forensic analysts and law enforcement agencies and causes great harm to unaware users. Our lab successfully utilizes NMR as an alternative to conventional GC-MS method to rapidly identify and quantify emerging cannabinoids. We have also optimized simple extraction technique for these designer herbal drugs prior to optimized HPLC separation and quantification. Our methods can be utilized to accelerate the accurate screening of designer drugs and to reduce evidence backlog in the battle with emerging ’Spice’ products.


April 2, 2015

Yu Chen, Ph.D., Department of Chemistry, Queens College - CUNY

Electrophilic Cyclizations of Alkynes-Facile Approaches to Heterocyclic and Carbocyclic Molecules

Palladium and gold-catalyzed as well as iodine monochloride-induced intramolecular electrophilic cyclizations of functionally substituted alkynes will be discussed. These regioselective annulations represent new and efficient synthetic approaches to carbocyclic and heterocyclic molecules, including isoxazoles, isoquinolines, indenones, and dibenzoannulen-5-ones. These approaches utilize palladium or gold catalyzed reactions as the key steps towards the production of the final target molecules or intermediate compounds. The new methods start from readily available starting materials and only consist of facile and user-friendly synthetic conditions, while they will serve as valuable tools for the preparation of compounds covering a broad spectrum of fields including synthetic and medicinal chemistry, and the material sciences.


April 24, 2015

15th Annual Chemistry Challenge

This is a chemistry knowledge competition between student teams from area two- and four-year institutions. Thirty multiple choice questions (approximately 75% General and 25% Organic Chemistry) are asked in a friendly and exciting atmosphere that brings colleges and their students and faculty together. Each team is made of three members and all are welcome. Medals will be awarded to first, second and third place winners. Accept the Challenge!!

Time: 5:00pm dinner, 6:00pm Chemistry Challenge
Place: Queensborough Community College, Science Bldg S-112



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